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Pharmacology
Prior to Pharmacology
Patents





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Pharmacology
59.
K. K. Coti, Y. Wang, C.-C. Chen, Z. T. F. Yu, M. Selke, W. Lu, W.-Y.
Lin, C. K.-F. Shen, A. Yeh, H.-R. Tseng (2008) Dynamic Micro-/Nano-Reactor.
Submitted.
58.
W.-Y. Lin, Y.-C. Chen, K. Liu, Y. Wang, S. Olma, K. Faull, N.
Satyamurthy, M. E. Phelps, R. M. van Dam, C. K.-F. Shen, H.-R. Tseng
(2008) Radiochemical Syntheses of 3′-Deoxy-3′-[18F]Fluoro-L-Thymidine
and 2-(1-{6-[(2 [18F]Fluoroethyl)Methylamino]-2-Naphthyl} Ethylidene)
Malononitrile Using an Integrated Microfluidic Device. Submitted.
57.
Z. T. F. Yu, K. Kamei, C. J. Shu, R. Silverman, C. G. Radu, O. N. Witte,
H.-R. Tseng (2008) An Integrated Microfluidic Chip for Parallel Culture
and Multiparametric Analysis of Murine and Human Cell Lines. Submitted.
56.
S. Hou, C. K.-F. Shen, Zeta T. F. Yu, S. Wang, X. Fang, H.-R. Tseng (2008) Hydrodynamically Focused Stream as a Dynamic Template for
Electrochemical Growth of Single Conducting Polymer Nanowires. Angew. Chem. Int. Ed. 47:
ASAP.

55.
K. K. Coti, Y. Wang, J. Wang, M. M. Alam, J.-J. Shyue, A. Yeh, W. Lu, N. P. Padture, H.-R. Tseng(2007) Individually Addressable Crystalline Conducting polymer
Nanowires in a Microelectrode Sensor Array. Nanotechnology 18: 424021 (7 pp).

54.
G.Sui,C.-C. Lee, K. Kamei, H.-J. Li, J.-Y. Wang, J. Wang, H. R. Herschman, H.-R. Tseng (2007) A Microfluidic Platform for Sequential Ligand Labeling and Cell Binding
Analysis. Biomedical Microdevices 9: 301-305

53.
G. Sui, J. Wang, H.-R. Tseng (2006) Playing Reactions in Hand. Nano
Today, 1: 6-7.

52.
G. Sui, J. Wang, C.C. Lee, S. P. Lee, J. V. Leyton, A. M. Wu, H.-R.
Tseng (2006) Solution-Phase Surface Modification in Intact
Poly(dimethylsiloxane) Microfluidic Channels. Anal. Chem. 78:
5543-5551.

51.
J. Wang, G. Sui, V. P. Mocharla, R. J. Lin, M. E. Phelps, H. C. Kolb,
H.-R. Tseng (2006) Integrated Microfluidics for Parallel Screening of In
Situ Click Chemistry Library. Angew. Chem. Int. Ed. 45:
5276-5281.

50.
J. Wang, Y. L. Bunimovich, G. Sui, S. Savvas, Y. Guo, J. R. Heath, H.-R.
Tseng (2006) Electrochemical Fabrication of Conducting Polymer Nanowires
in an Integrated Microfluidic System. Chem. Commun. 3075-3077.

49.
C.-C. Lee, G. Sui, A.
Elizarov, C. J. Shu, Y.-S. Shin, A. N. Doole, D. Stout, O. N. Witte, H.
C. Kolb, N. Satyamurthy, J. R. Heath, M. E. Phelps, S. R. Quake, H.-R.
Tseng (2005) Multi-Step Synthesis of a Radiolabeled Imaging Probe in
Integrated Microfluidics. Science 310: 1793-1796.

48.
M. M.
Alam, J. Wang, Y. Guo, S. P. Lee, H.-R. Tseng (2005) Electrolyte-Gated
Transistors Based on Conducting Polymer Nanowire Junction Arrays. J. Phys. Chem. B 109: 12777-12784.

47.
J.
Wang, M. M. Alam, H.-R. Tseng (2005) Individually Addressable Conducting
Polymer Nanowire Electrode Junctions That Function as Gas Sensors. Mater. Res. Soc. Symp. Proc. 828: A2.10.1.
46.
J.
Wang, S. Chan, R. R. Carlson, Y. Luo, G. Ge, R. S. Ries, J. R. Heath,
H.-R. Tseng (2004) Electrochemically Fabricated Polyaniline
Nanoframework Electrode Junctions That Function as Resistive Sensors.
Nano Lett.
4:
1693-1697.

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Prior
to Pharmacology
45. B.
Brough, B. H. Northrop, J. J. Schmidt, H.-R. Tseng, K. N. Houk, J. F.
Stoddart, C.-M. Ho (2006) Evaluation of Synthetic Linear Motor-molecule
Actuation Energetics. Proc. Natl. Acad. Sci. USA. 103:
8583-8588.

44.
E. DeIonno, H.-R. Tseng, D. D. Harvey, J. F. Stoddart, J. R. Heath
(2006) Infrared Spectroscopic Characterization of [2]Rotaxane Molecular
Switch Tunnel Junction Devices. J. Phys. Chem. B 110: 7609-7612.

43.
V.
Balzani, M. Clemente-León, A. Credi, M. Semeraro, M. Venturi, H.-R. Tseng,
S. Wenger, S. Saha, J. F. Stoddart (2006) A Comparison of
Shuttling Mechanisms in Two Constitutionally Isomeric Bistable
Rotaxane-Based Sunlight-Powered Nanomotors. Aust. J. Chem. 59: 193-206.

42.
P. M.
Mendes, W. Lu, H.-R. Tseng, S. Shinder, T. Iijima, M. Miyaji, C. M. Knobler,
J. F. Stoddart (2006) A Soliton Phenomenon in Langmuir
Monolayers of Amphiphilic Bistable Rotaxanes. J. Phys. Chem. B 110: 3845-3848.

41.
S.
Saha, L. E. Johansson, A. H. Flood, H.-R. Tseng, J. I. Zink, J. F.
Stoddart (2005) A Photoactive Molecular Triad as a Nanoscale Power
Supply for a Supramolecular Machine.
Chem. Eur. J. 11: 6846-6858.

40.
K. Nørgaard, B. W. Laursen, S. Nygaard, K. Kjaer, H.-R. Tseng, A.H. Flood,
J. F. Stoddart, T. Bjørnholm (2005) Structural Evidence of Mechanical
Shuttling in Condensed Monolayers of Rotaxane Molecules. Angew. Chem. Int. Ed. 43:
7035-7039.

39.
T. D.
Nguyen, H.-R. Tseng, P. C. Celestre, A. H. Flood, Y. Liu, J. F.
Stoddard, J. I. Zink (2005) A Reversible Molecular Valve. Proc. Natl. Acad. Sci. USA. 102:
10029-10034.

38.
Y.
Liu, A. H. Flood, P. A. Bonvallet, S. A. Vignon, B. H. Northrop, H.-R.
Tseng, J. O. Jeppesen, T, J. Huang, B. Brough, M. Baller, S. Magonov, S.
D. Solares, W. A. Goddard, C.-M. Ho, J. F. Stoddart (2005) Linear
Artificial Molecular Muscles. J.
Am. Chem. Soc. 127: 9745-9759.

37.
S. S.
Jang, Y. H. Jang, Y.-H. Kim, W. A., III Goddard, A. H. Flood, B. W.
Laursen, H.-R. Tseng, J. F. Stoddart, J. O. Jeppesen, J. W. Choi, D. W.
Steuerman, E. DeIonno, J. R. Heath (2005) Structures and Properties of
Self-Assembled Monolayers of Bistable [2]Rotaxanes on Au (111) Surfaces
from Molecular Dynamics Simulations Validated with Experiment. J. Am.
Chem. Soc 127: 1563-1575.

36.
A. H.
Flood, A. J. Peters, S. A. Vignon, D. W. Steuerman, H.-R. Tseng, S. K.
Kang, J. R. Heath, J. F. Stoddart (2004) The Environmental Responsive
Electrochemical Switching Mechanism Displayed by Bistable Donor-Acceptor
Catenanes and Rotaxanes. Chem. Eur. J. 10: 6558-6564.

35.
D. W.
Steuerman, H.-R. Tseng, A. J. Peters, A. H. Flood, J. O. Jeppesen, K. A.
Nielsen, J. F. Stoddart, J. R. Heath (2004) The Dynamics of Molecular
Mechanical Switches within Solid-State Polymer Electrolytes. Angew.
Chem. Int. Ed. 43: 6486-6491.

34.
T. J.
Huang, B. Brough, C.-M. Ho, Y. Liu, A. H. Flood, P. A. Bonvallet, H.-R.
Tseng, J. F. Stoddart, M. Baller, S. Magonov (2004) A Nanomechanical
Device Based on Linear Molecular Motors. Appl. Phys. Lett. 85:
5391-5393.

33.
F.
Marchioni, M. Venturi, P. Ceroni, V. Balzani, M. Belohardsky, A. M.
Elizarov, H.-R. Tseng, J. F. Stoddart (2004) Complete Charge Pooling is
Prevented in Viologen-based Dendrimers by Self-Protection. Chem. Eur.
J. 10: 6361-6368.

32.
T.
Iijima, S. A. Vignon, H.-R. Tseng, T. Jarrosson, J. K. M. Sanders, F.
Marchioni, M. Venturi, E. Apostoli, V. Balzani, J. F. Stoddart (2004)
Redox-Controllable Donor-Acceptor Neutral [2]Rotaxanes. Chem. Eur. J.
10: 6375-6392.

31.
S.
Saha, E. Johansson, A. H. Flood, H.-R. Tseng,J. I.
Zink, J. F. Stoddart (2004) Powering a Supramolecular Machine with a
Photoactive Molecular Triad. Small 1: 87-90.

30.
T. J.
Huang, H.-R. Tseng, L. Sha, W. Lu, A. H. Flood, B. Brough, B. Yu, P. C.
Celestre, P. J. Chang, J. F. Stoddart, C.-M. Ho (2004) Mechanical
Shuttling of Linear Motor-Molecules in Condensed Phased on Solid
substrates. Nano Lett. 4: 2065-2071.

29.
S. A.
Vignon, T. Jarrosson, T. Iijima, H.-R. Tseng, J. K. M. Sanders, J. F.
Stoddart (2004) Switchable Neutral Bistable Rotaxanes. J. Am. Chem.
Soc. 126: 9884-9885.

28.
C. Lee,
C. W. Frank, T. Yamamoto, H.-R. Tseng, A. H. Flood, J. F. Stoddart
(2004) Langmuir and Langmuir-Blodgett Films of Amphiphilic Bistable
[2]Rotaxanes.
Langmuir 20: 5809-5828.

27.
R. Hernandez, H.-R. Tseng, J. W. Wong, J. F. Stoddart, J. I. Zink (2004)
An Operational Supramolecular Nanovalve. J. Am. Chem. Soc. 126:
3370-3371.

26.
S.
Kang, S. A. Vignon, H.-R. Tseng, J. F. Stoddart (2004) Molecular Shuttle
Based on Tetrathiafulvalene Units and 1,5-Dioxynaphthalene Ring Systems.
Chem. Eur. J. 10: 2555-2564.

25.
H.-R.
Tseng, D. Wu, N. X. Fang, X. Zhang, J. F. Stoddart (2004) The
Metastability of an Electrochemical Controlled Nanoscale Machine on Gold
Surfaces. ChemPhysChem 5: 111-116.

24.
H.-R.
Tseng, P. C. Celestre, J. Perkins, J. O. Jeppesen, J. F. Stoddart, P. A.
Di Fabio, R. Ballardini, V. Balzani, M. T. Gandolfi, M. Venturi (2004)
Redox-Controllable Amphiphilic [2]Rotaxanes. Chem. Eur. J. 10:
155-172.

23.
F.
Marchioni, M. Venturi, A. Credi, V. Balzani, M. Belohradsky, A. M.
Elizarov, H.-R. Tseng, J. F. Stoddart (2004) Polyvalent Scaffold.
Counting the Number of Seats Available for Eosin Guest Molecules in
Viologen-Based Host Dendrimers. J. Am. Chem. Soc. 126: 568-573.

22.
H.-R.
Tseng, P. C. Celestre, J. F. Stoddart (2004) An Integrated
System-Oriented Approach to Molecular Electronics. Macromolecular
Nano-Structure Materials (N. Ueyama, A. Harada, Eds.) Springer-Verlag:
Germany : 1-25.
21.
S. A.
Vignon, J. Wang, H.-R. Tseng, J. F. Stoddart (2004) Helical Chirality in
Donor-Acceptor Catenanes. Org. Lett. 6: 1095-1098.

20.
D. Wu,
X. Yin, X. Zhang, H.-R. Tseng, J. F. Stoddart (2003) In Situ Infrared
Spectroscopic Studies of Molecular Behavior in Nanoelectronic Devices. IEEE-NANO 2: 606-608.

19.
T. J.
Huang, A. Flood, C.-W. Chu, S. Kang, T.-F. Guo, T. Yamamoto, H.-R.
Tseng, B.-D. Yu, Y. Yang,
J. F. Stoddart, C.-M. Ho (2003) In situ Infrared Spectroscopic Studies
of Molecular Behavior in Nanoelectronic Devices. IEEE-NANO 2: 698-701.

18.
M. R.
Bryce, G. Cooke, F. M. A. Dunclairoir, P. John, D. F. Perepichka, N.
Polwart, V. M. Rotello, H.-R. Tseng, J. F. Stoddart (2003)
Electrochemically Controllable Surfaces with Three-Pole Binding
Properties. J. Mater. Chem. 13: 2111-2117.

17.
H.-R.
Tseng, S. A. Vignon, J. F. Stoddart (2003) Toward Chemically Controlled
Nanoscale Molecular Machinery. Angew. Chem. Int. Ed. 42:
1491-1495.

16.
H.-R.
Tseng, S. A. Vignon, P. C. Celestre, J. F. Stoddart, A. J. P. White, D.
J. Williams (2003) Dynamic Chemistry: Keen Selection in the Face of
Stereochemical Diversity in Mechanically Bonded Compounds. Chem. Eur.
J. 9: 543-556.

15.
T.
Yamamoto, H.-R. Tseng, J. F. Stoddart, V. Balzani, A. Credi, F.
Marchioni, M. Venturi (2003) Redox-Induced Ring Shuttling and Evidence
for Folded Structures in Long and Flexible Two-Station Rotaxanes.
Collect. Czech. Chem. Comm. 68: 1488-1514.

14.
H.-R.
Tseng, S. A. Vignon, J. F. Stoddart (2003) Molecular Muscles Based on
Mechanically Interlocked Molecules. Polymer Preprints 44:
377-378.

13.
J. F.
Stoddart, H.-R. Tseng (2003) Molecular Electronics Based on Mechanically
Interlocked Molecules. Polymer Preprints 44: 381-382.

12. M. R.
Diehl, D. W. Steuerman, H.-R. Tseng, S. A. Vignon, A. Star, J. F.
Stoddart, J. R. Heath (2003) Single-Walled Carbon Nanotube Based
Molecular Switch Tunnel Junctions. ChemPhysChem
4:
1335-1339.

11.
H. Yu,
Y. Luo, K. Beverley, H.-R. Tseng, J. F. Stoddart, J. R. Heath (2003) The
Molecule / Electrode Interfaces in Single-Molecule Transistors.
Angew. Chem. Int. Ed. 42: 5706-5711.

10.
Y. Luo,
C. P. Collier, J. O. Jeppesen, K. A. Nielsen, E. DeIonno, G. Ho, J.
Perkins, H.-R. Tseng, T. Yamamoto, J. F. Stoddart, J. R. Heath (2002)
Two-Dimensional Molecular Electronics Circuits. ChemPhysChem 3:
519-525.

9.
R.
Ballardini, V. Balzani, M. Clemente-Leon, A. Credi, M. T. Gandolfi, E.
Ishow, J. Perkins, J. F. Stoddart, H.-R. Tseng, S. Wenger (2002)
Photoinduced Electron Transfer in a Triad That Can Be Assembled /
Disassembled by Two Different External Inputs. Toward Molecular-Level
Extension Cables. J. Am. Chem. Soc. 124: 12786-12795.
8. J. F.
Stoddart, H.-R. Tseng (2002) Chemical Synthesis Gets a Fillip from
Molecular Recognition and Self-Assembly Processes. Proc. Natl. Acad.
Sci. USA 99: 4797-4800.

7. H.-R.
Tseng, J. F.Stoddart (2002) Molecular Switches and Machines Using Arene
Building Blocks. Modern Arene Chemistry (D. Astruc, Ed.) Wiley-VCH:
Weinheim : 574-599.
6. H.-R.
Tseng, C.-F. Lee, L.-M.; Yang, T.-Y. Luh (1999) Umpolung of the
Carbon-Sulfur Bonds. Novel Synthesis of Substituted Allenes from
Propargylic Ditioacetals. J. Org. Chem. 64: 8582-8587.

5. H.-R.
Tseng, T.-Y. Luh (1997) Novel Coupling Reaction of Dithioacetals with
Organocuprate Reagents. Propargylic Dithioacetal as a
Allene-1,3-Zwitterion Synthon. J. Org. Chem. 62: 4568-4569.

4. C.-T.
Lin, N.-J. Wang, H.-R. Tseng, T.-C. Chou (1997) Synthesis and
Transannular Reactions of a Polycylic Compound Containing Three Parallel
Face-to-Face Double Bonds. J. Org. Chem. 62: 4857-4861.

3. H.-R.
Tseng, T.-Y. Luh (1996) Reactions of Geminal Dication Synthons with
Geminal Dianionic Species. Cross-Coupling of Benzylic Dithioacetals with
Nickela- Bismetallic Reagents. Organometallics 15: 3099-3102.

2. H.-R.
Tseng, T.-Y. Luh (1996) Propargylic Dithioacetal as an Allene
1,3-Dication Synthon. Nickel-Catalyzed Cross-Coupling Reaction of
Propargylic Dithioacetals with Grignard Reagents. J. Org. Chem.
61: 8685-8686.

1.
H.-R.
Tseng, T.-S. Chou (1995) Regioselective Substitution Reactions of Zinc
Sulfolenylates. Tetrahedron Letts. 36: 7105-7108.

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Patent Applications
1.
Provisional Application, “An Integrated Microfluidic Blood Sampler
for Mice” UCLA Case No.
2005-659-1.
(Disclosure date: May 09, 2005)
2.
Provisional Application, “A Simplified Approach for Surface Modification
of Polymer-Based Microfluidic Devices” UCLA Case No.
2005-685-1.
(Disclosure date: May 31, 2005)
3.
Patent
Application “Electrochemically fabricated conducting polymer nanowire
sensors” PCT Int. Appl. (2006), WO
2006042276.
4.
Patent
Application “Microfluidic devices with chemical reaction circuits” PCT
Int. Appl. (2006), WO
2006071470.
5. Provisional Application, “Development of High-Affinity
PET-Probes for High Performance Molecular Imaging” PCT Int. Appl.
(2006), WO
2006778430.
6.
Provisional Application, “Device for High Sensitivity Quantitation of
Radioisotope Concentrations in a Microfluidic Platform” UCLA Case No.
2006-388-1.
(Disclosure date: January 11, 2006)
7. Provisional Application, “Microfluidic Platform for Cell
Culture and Assay” UCLA Case No.
2007-067.
(Disclosure date: August 4, 2006)
8. Provisional Application, “Microfluidic Cell Culture Array for
Drug Screening and Imaging Probe Discovery” UCLA Case No.
2007-562.
(Disclosure date: April 13, 2007)
9. Provisional Application, “Integrated Microfluidics for
Parallel Screening of Chemical Reactions” UCLA Case No.
2007-570.
(Disclosure date: May 23, 2007)
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