Selected Recent Publications:

Wei Guo, Joseph L. Lasky, Chun-Ju Chang, Sherly Mosessian, Xiaoman Lewis, Yun Xiao, Jennifer E. Yeh, James Y. Chen, M. Luisa Iruela-Arispe, Marileila Varella-Garcia & Hong Wu
Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation
Nature 453, 529-533.

Jiao J, Wang S, Qiao R, Vivanco I, Watson PA, Sawyers CL, Wu H
Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development.
Cancer Res 2007;67:6083–91.
    Correction: Role of Pten in Hormone Refractory Prostate Cancer
    Cancer Res 2007;67:7937.

Lei Q, Jiao J, Xin L, Chang CJ, Wang S, Gao J, Gleave ME, Witte ON, Liu X, Wu H
NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.
Cancer Cell. 2006 May;9(5):367-78.

Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H
Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes.
Mol Cell Biol. 2006 Apr;26(7):2772-81

Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H.
Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation.
Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1480-5.

Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H.
PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry.
Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):111-6

Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas.
Cancer Cell. 2005 Sep;8(3):185-95.

Chang CJ, Freeman DJ, Wu H.
PTEN regulates Mdm2 expression through the P1 promoter.
J Biol Chem. 2004 Jul 9;279(28):29841-8.

Wong KA, Kim R, Christofk H, Gao J, Lawson G, Wu H
Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life.
Mol Cell Biol. 2004 Jun;24(12):5577-86.

Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H.
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer.
Cancer Cell. 2003 Sep;4(3):209-21.

Tsai PT, Lee RA, Wu H.
BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis.
Blood. 2003 Aug 14

Freeman DJ, Li AG, Wei G, Li HH, Kertesz N, Lesche R, Whale AD, Martinez-Diaz H, Rozengurt N, Cardiff RD, Liu X, Wu H. 
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms.
Cancer Cell. 2003 Feb;3(2):117-30.

Anzelon AN, Wu H, Rickert RC.
Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function.
Nat Immunol. 2003 Mar;4(3):287-94.

Jegalian AG, Wu H.
Differential roles of SOCS family members in EpoR signal transduction.
J Interferon Cytokine Res. 2002 Aug;22(8):853-60.

Li G, Robinson GW, Lesche R, Martinez-Diaz H, Jiang Z, Rozengurt N, Wagner KU, Wu DC, Lane TF, Liu X, Hennighausen L, Wu H.
Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland.
Development. 2002 Sep 1;129(17):4159-4170.

Stiles B, Gilman V, Khanzenzon N, Lesche R, Li A, Qiao R, Liu X, Wu H.
Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis.
Mol Cell Biol. 2002 Jun;22(11):3842-51.

Lesche R, Groszer M, Gao J, Wang Y, Messing A, Sun H, Liu X, Wu H.
Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene.
Genesis. 2002 Feb;32(2):148-9.

Jegalian AG, Acurio A, Dranoff G, Wu H.
Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukin 3.
Blood. 2002 Apr 1;99(7):2603-5.

Jegalian AG, Wu H.
Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: two routes for STAT5 target gene induction by erythropoietin.
J Biol Chem. 2002 Jan 18;277(3):2345-52.

Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, Zack JA, Kornblum HI, Liu X, Wu H.
Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.
Science. 2001 Dec 7;294(5549):2186-9.
    Comments:
    Penninger JM, Woodgett J.
    Stem cells. PTEN--coupling tumor suppression to stem cells?
    Science. 2001 Dec 7;294(5549):2116-8.
    Morrison SJ.
    Pten-uating neural growth
    Nat Med. 2002 Jan;8(1):16-8.

Lee R, Kertesz N, Joseph SB, Jegalian A, Wu H.
Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis.
Blood. 2001 Sep 1;98(5):1408-15.

Liliental,J., Lesche, R., Moon, S-Y., Mamillapalli, R., Gavrilova, N., Sun, H., Zheng, Y., and Wu, H.
Genetic Deletion of the Pten Tumor Suppressor Gene Promotes Cell Motility by Activation of Rac1 and Cdc42 GTPases.
Curr Biol. 2000 Apr 6;10(7):401-4.

Sun, H., Lesche, R., Li, DM., Liliental, J., Zhang, H., Gao, J., Garvarina, N., Mueller, B., Liu, X. and Wu, H.
PTEN Modulates Cell Cycle Prograssion and Cell Survival by Regulating PIP3 and AKT/PKB Signaling Pathway.
Proc Natl Acad Sci U S A. 1999 May 25;96(11):6199-204.

Wu, H., Lee, S-H, Gao, J., Liu, X. and Iruela-Arispe, L.
Inactivation of Erythropoietin Leads to Defects in Cardiac Morphogenesis.
Development. 1999 Aug;126(16):3597-605.