Wu/Liu Lab Members

Postdoctoral Fellows Graduate Students Laboratory Personnel Undergraduates Laboratory Alumni

Hong Wu, M.D., Ph.D.


Director, Institute for Molecular Medicine (IMED), UCLA
Professor, Molecular & Medical Pharmacology, UCLA
Member, Jonsson Cancer Center, UCLA
Member, Molecular Biology Institute, UCLA

Office: CHS   23-214
Office Phone: 310-825-5160
Office Fax:310 267 0242
Lab: CHS  23-234
Lab Phone: 310 825 5454

Hong Wu is the Director of the Institude for Molecular Medicine (IMED), a Professor of Molecular and Medical Pharmacology at UCLA School of Medicine and a member of UCLA Molecular Biology Institute and Jonsson Comprehensive Cancer Center. She is the Director of the UCLA Molecular Genetics Technology Center and the co-director of Cancer Stem Cell Program area of the newly formed UCLA Institute for Stem Cell Biology and Medicine. Dr. Wu received her M.D. degree from Beijing Medical College, China, and her Ph.D. degree in biological chemistry from Harvard Medical School, working with Rudolf Jaenisch at the Whitehead Institute for Biomedical Research. She was a Damon Runyon-Walter Winchell postdoctoral fellow with Harvey Lodish at the Whitehead Institute for Biomedical Research, MIT. Her laboratory studies the signal transduction pathways controlled by the PTEN tumor suppressor gene, using various genetically engineered animal tumor models.

Collaborator
Xin Liu, M.D., Ph.D.


Associate Professor, Molecular & Medical Pharmacology, UCLA
Department of Pathology and Laboratory Medicine

Our research aims at understanding the molecular basis of nervous system development, plasticity, and neurodegenerative diseases. Our main focus is on the function of Delta-catenin (d-cat). D-cat is a member of the Armadillo protein family which interacts with Presenilin1 (PS1) and is expressed exclusively in the brain. We developed mice that lack d-cat expression and found that d-cat mutants have a significant deficiency in learning and LTP. Currently, we are studying the mechanism of delta catenin regulation trying to dissect out d-catís role in synaptic adherens and Alzheimer's disease.



Lab Members