Our Papers

2007 -

_BMC 

Lihao Meng, Gregory A Michaud, Janie S Merkel, Fang Zhou, Jing Huang, Dawn R Mattoon and Barry Schweitzer (2008) Protein kinase substrate identification on functional protein arrays. BMC Biotechnol. 8(1):22.

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cover Jonathan P. Saxe, Hao Wu, Theresa K. Kelly, Michael E. Phelps, Yi E. Sun*, Harley I. Kornblum*, and Jing Huang* (2007) A Phenotypic Small-Molecule Screen Identifies an Orphan Ligand-Receptor Pair that Regulates Neural Stem Cell Differentiation. Chem Biol. 14(9):1019-1030.

Preview: Rajesh Ambasudhan and Sheng Ding (2007) An "Orphan" Finds a Home in NSC Regulation. Chem Biol. 14(9):974-975.

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2002 - 2007

   Ana M. Sanchez, Diane Thomas, Eugene J. Gillespie, Robert Damoiseaux, Joseph Rogers, Jonathan P. Saxe, Jing Huang, Marianne Manchester, and Kenneth A. Bradley (2007) Amiodarone and bepridil inhibit anthrax toxin entry into host cells. Antimicrob Agents Chemother. 51(7):2403-2411.

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   Fulai Jin, Larisa Avramova, Jing Huang* & Tony Hazbun* (2007) A yeast two-hybrid smart-pool-array system for protein interaction mapping. Nat Methods. 4(5):405-407.

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   Mara C. Duncan, David G. Ho, Jing Huang, Michael E. Jung, Gregory S. Payne (2007) Composite synthetic lethal identification of membrane traffic inhibitors. Proc Natl Acad Sci USA. 104(15):6235-6240.

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   Heng Zhu* and Jing Huang* (2007) A combined force of chemical genetics and protein microarrays. In Functional Protein Microarrays in Drug Discovery, Paul F. Predki, ed., CRC Press.  

   Masakazu Kamata*, Raymond P. Wu*, Dong Sung An, Jonathan P. Saxe, Robert Damoiseaux, Michael E. Phelps, Jing Huang, Irvin S.Y. Chen (2006) Cell-based chemical genetic screen identifies damnacanthal as an inhibitor of HIV-1 Vpr induced cell death. Biochem Biophys Res Commun. 348(3):1101-1106. PDF  

cover Fulai Jin, Tony Hazbun, Gregory A Michaud, Michael Salcius, Paul F Predki*, Stanley Fields* & Jing Huang* (2006) A pooling-deconvolution strategy for biological network elucidation. Nat Methods. 3(3):183-189.

News and Views: Nicolas Thierry-Mieg (2006) Pooling in systems biology becomes smart. Nat Methods. 3(3):161-162.

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 Xie MW, Jin F*, Hwang H*, Hwang S*, Anand V, Duncan MC, Huang J. (2005) Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method. Proc Natl Acad Sci USA. 102(20):7215-7220.

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  Huang J, Zhu H*, Haggarty SJ*, Spring DR*, Hwang H, Jin F, Snyder M, Schreiber SL. (2004) Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proc Natl Acad Sci USA. 101(47):16594-16599.

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  Paulmurugan R, Massoud TF, Huang J, Gambhir SS. (2004) Molecular imaging of drug-modulated protein-protein interactions in living subjects. Cancer Res. 64(6):2113-2119.

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  Zewail A*, Xie MW*, Xing Y, Lin L, Zhang PF, Zou W, Saxe JP, Huang J. (2003) Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin. Proc Natl Acad Sci USA. 100(6): 3345-3350.

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Pre - 2002

  Huang J, Haggarty SJ, Schreiber SL. (2000) Understanding target-of-rapamycin function through small molecules and microarrays. FASEB J. 2000 14(8):1410.
  Huang J, Schreiber SL. (1997) A yeast genetic system for selecting small molecule inhibitors of protein-protein interactions in nanodroplets. Proc Natl Acad Sci USA. 94(25):13396-13401.  Editorial: Sikorski R, Peters R. (1998) Droplet discovery. Science. 279(5349):412-413. PDF  

  Huang J, Weintraub H, Kedes L. (1998) Intramolecular regulation of MyoD activation domain conformation and function. Mol Cell Biol. 18(9):5478-5484.

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  Sartorelli V, Huang J, Hamamori Y, Kedes L. (1997) Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C. Mol Cell Biol. 17(2): 1010-1026.

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  Huang J, Blackwell TK, Kedes L, Weintraub H. (1996) Differences between MyoD DNA binding and activation site requirements revealed by functional random sequence selection. Mol Cell Biol. 16(7):3893-3900.  PDF  
cover Blackwell TK, Huang J, Ma A, Kretzner L, Alt FW, Eisenman RN, Weintraub H. (1993) Binding of Myc proteins to canonical and non-canonical DNA sequences. Mol Cell Biol. 13(9):5216-5224.

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